Pioneering Tissue Perfusion Monitoring: IscAlert and Beyond - Discover the Power of pCO2 Measurement in Clinical Practice

1.
Biological basis for PCO2 as a detector of ischemia.

Tønnessen TI.

Acta Anaesthesiol Scand. 1997 Jun;41(6):659-69. doi: 10.1111/j.1399-6576.1997.tb04764.x.

PMID: 9241323 Review. No abstract available.

2.
A new biomedical sensor for measuring PCO2.

Mirtaheri P, Grimnes S, Martinsen OG, Tønnessen TI.

Physiol Meas. 2004 Apr;25(2):421-36. doi: 10.1088/0967-3334/25/2/002.

PMID: 15132308

3.
[CO2 pressure used in the diagnosis of ischemia].

Kvarstein G, Tønnessen TI.

Tidsskr Nor Laegeforen. 1997 Nov 30;117(29):4251-5.

PMID: 9441471 Review. Norwegian.

4.
Detection of organ ischemia during hemorrhagic shock.

Kvarstein G, Mirtaheri P, Tønnessen TI.

Acta Anaesthesiol Scand. 2003 Jul;47(6):675-86. doi: 10.1034/j.1399-6576.2003.00134.x.

PMID: 12803584

5.
Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time†.

Pischke SE, Hyler S, Tronstad C, Bergsland J, Fosse E, Halvorsen PS, Skulstad H, Tønnessen TI.

Br J Anaesth. 2015 Mar;114(3):414-22. doi: 10.1093/bja/aeu381. Epub 2014 Nov 12.

PMID: 25392231

6.
Cerebral perfusion and metabolism with mean arterial pressure 90 vs. 60 mmHg in a porcine post cardiac arrest model with and without targeted temperature management.

Skåre C, Karlsen H, Strand-Amundsen RJ, Eriksen M, Skulberg VM, Sunde K, Tønnessen TI, Olasveengen TM.

Resuscitation. 2021 Oct;167:251-260. doi: 10.1016/j.resuscitation.2021.06.011. Epub 2021 Jun 21.

PMID: 34166747

7.
Tissue gas tensions and tissue metabolites for detection of organ hypoperfusion and ischemia.

Waelgaard L, Dahl BM, Kvarstein G, Tønnessen TI.

Acta Anaesthesiol Scand. 2012 Feb;56(2):200-9. doi: 10.1111/j.1399-6576.2011.02572.x. Epub 2011 Nov 21.

PMID: 22103593

8.
Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology.

Pischke SE, Tronstad C, Holhjem L, Halvorsen PS, Tønnessen TI.

Eur J Cardiothorac Surg. 2012 Jul;42(1):157-63. doi: 10.1093/ejcts/ezr278. Epub 2012 Jan 20.

PMID: 22290904

9.
Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization.

Tronstad C, Pischke SE, Holhjem L, Tønnessen TI, Martinsen OG, Grimnes S.

Physiol Meas. 2010 Sep;31(9):1241-55. doi: 10.1088/0967-3334/31/9/013. Epub 2010 Aug 11.

PMID: 20702916

10.
Hepatic and abdominal carbon dioxide measurements detect and distinguish hepatic artery occlusion and portal vein occlusion in pigs.

Pischke SE, Tronstad C, Holhjem L, Line PD, Haugaa H, Tønnessen TI.

Liver Transpl. 2012 Dec;18(12):1485-94. doi: 10.1002/lt.23544.

PMID: 22961940

11.
Miniaturization of a biomedical gas sensor.

Mirtaheri P, Omtveit T, Klotzbuecher T, Grimnes S, Martinsen OG, Tønnessen TI.

Physiol Meas. 2004 Dec;25(6):1511-22. doi: 10.1088/0967-3334/25/6/015.

PMID: 15712728

12.
PCO2 electrodes at the surface of the kidney detect ischaemia.

Tønnessen TI, Kvarstein G.

Acta Anaesthesiol Scand. 1996 May;40(5):510-9. doi: 10.1111/j.1399-6576.1996.tb04481.x.

PMID: 8792878

13.
Methods for detecting local intestinal ischemic anaerobic metabolic acidosis by PCO2.

Rozenfeld RA, Dishart MK, Tønnessen TI, Schlichtig R.

J Appl Physiol (1985). 1996 Oct;81(4):1834-42. doi: 10.1152/jappl.1996.81.4.1834.

PMID: 8904606

14.
Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia.

Hyler S, Pischke SE, Halvorsen PS, Espinoza A, Bergsland J, Tønnessen TI, Fosse E, Skulstad H.

J Am Soc Echocardiogr. 2015 Apr;28(4):486-94. doi: 10.1016/j.echo.2014.12.014. Epub 2015 Jan 27.

PMID: 25636368

15.
Tissue carbon dioxide tension: a putative specific indicator of ischemia in porcine latissimus dorsi flaps.

Kvarstein G, Barstad M, Mirtaheri P, Tønnessen TI.

Plast Reconstr Surg. 2003 Dec;112(7):1825-31. doi: 10.1097/01.PRS.0000091166.83956.39.

PMID: 14663226

16.
PCO(2) in the large intestine of mice, rats, guinea pigs, and dogs and effects of the dietary substrate.

Rasmussen H, Mirtaheri P, Dirven H, Johnsen H, Kvarstein G, Tønnessen TI, Midtvedt T.

J Appl Physiol (1985). 2002 Jan;92(1):219-24. doi: 10.1152/japplphysiol.00190.2001.

PMID: 11744663

17.
Gas supersaturation in the cecal wall of mice due to bacterial CO2 production.

Rasmussen H, Kvarstein G, Johnsen H, Dirven H, Midtvedt T, Mirtaheri P, Tønnessen TI.

J Appl Physiol (1985). 1999 Apr;86(4):1311-8. doi: 10.1152/jappl.1999.86.4.1311.

PMID: 10194217

18.
Detection of ischemia by PCO2 before adenosine triphosphate declines in skeletal muscle.

Kvarstein G, Mirtaheri P, Tønnessen TI.

Crit Care Med. 2004 Jan;32(1):232-7. doi: 10.1097/01.CCM.0000104948.41544.FC.

PMID: 14707584

19.
Microdialysis and CO2 sensors detect pancreatic ischemia in a porcine model.

Rydenfelt K, Strand-Amundsen R, Horneland R, Hødnebø S, Kjøsen G, Pischke SE, Tønnessen TI, Haugaa H.. PLoS One. 2022 Feb 10;17(2):e0262848. doi: 10.1371/journal.pone.0262848.

PMID: 35143517; PMCID: PMC8830677.

20.
Detection of ischemia by a biosensor measuring tissue carbon dioxide tension

Korslund J, Thorkildsen RD, Lindholm E, Strand-Amundsen R, Tønnessen TI, Røkkum M. JVS-Vascular Insights: An Open Access Publication from the Society for Vascular Surgery, Volume 3, 100166

21.
Cerebral perfusion and metabolism with mild hypercapnia vs. normocapnia in a porcine post cardiac arrest model with and without targeted temperature management.

Karlsen H, Strand-Amundsen RJ, Skåre C, Eriksen M, Skulberg VM, Sunde K, Tønnessen TI, Olasveengen TM.

Resusc Plus. 2024 Mar 12;18:100604. doi: 10.1016/j.resplu.2024.100604. PMID: 38510376;

PMCID: PMC10950799.